EFFECT OF ASPIRIN ON FERTILITY OF MALE WHITE MICE

Abstract

Thirty mice males were divided into three groups.First group was injected
with (50 mg/kg) of aspirin,the second was injected with(150 mg/kg)and the third
group termed as control group and injected with distiled water.The experiment
continued for four weeks .In the end of the experiment half of males were mated
with untreated females.The number and weight of litters were recorderd in
addition to the length of gestation .The second half of males were anesthetized, then
epididymis was removed.The total sperm count,the percentage of live and dead
sperms and the percentage of motile and non-motile were counted .The results
showed that there was a significant decrease(p<0.05) in the litters number and
significant increase(p<0.05) in the period of pregnancy .Also there was a
significant decrease(P<0.01) in the percentage of live and motile sperms in the both
groups compared with control group .Also the percentage of dead and non-motile
sperms were increased significantly(P<0.01)in both groups compared with control
group. These effects of aspirin maybe due to the action of aspirin as prostagland
inhibitor.