Study of Changes for Total Sialic Acid and Lipid-Bound Sialic Acid Levels in Tuberculosis and Lung cancer

Abstract

Sialic acid (SA) have been used as one of laboratory markers in diagnosis a variety of
pathological conditions, and it have been found to be elevated in a number of different
cancers .Many studies have shown that mean values of total sialic acid (TSA) or lipid-bound
sialic acid (LSA) were higher in patients with cancer than in normal subjects .The aim of the
present study was to determine the serum of total sialic acid (TSA), lipid-bound sialic acid
(LSA),total protein (TP) and TSA/TP levels in the(Tuberculosis TB and Lung cancer LC )
compared with healthy controls , data analysis indicated a significant increase ( P=0.0001 ) in
TSA and LSA levels in (TB,LC) groups in comparison with healthy controls, no difference
was observed in TSA concentrations between (TB,LC) groups, no difference LSA levels were
observed when (TB) patients compared with healthy controls ,.The concentration of TP was
slightly elevated( P=0.042 ) in (TB,LC) groups comparison with healthy controls ,there was a
significant increased ( P=0.0001 ) in TSA/TP levels in (TB,LC) groups in comparison with
healthy controls.