Assessment of Immunoglobulins In The Serum Of Children With Shigellosis

Abstract

During a period of nine months from January 2006 to September 2006.
Sixty –two cases of shigellosis were collected at Nassiria Pediatric hospital
( Age ranged from one day to five years). A total of 317 cases suffering form
bloody diarrhea , out of 317 stool samples , 62 bacterial isolates were
obtained represent 19.5% from all cases of diarrhea ,The isolates identified
were, Shigella dysenteriae , Shigella sonnei , Shigella boydii , and Shigella
flexneri .The percentage of each are , 22(35.4%) , 19(30.6%) , 13(20.9%) ,
8(12.9%) respectively . Shigellosis was predominant in those below one year
of age (32.2%) .The concentration of total protein level in the serum of
children with shigellosis was normal in all age groups , while albumin was low
, alpha 1 – globulin concentration was high , alpha 2 –globulin increased
slightly with advancing age , beta – globulin concentration in serum of
children was normal , gamma globulin concentration was slightly elevated in
most age groups . Forty – seven children (75.8%) are found to have high level
of lmmunoglobulins concentration while fifteen children ( 24.2%) have low
levels of lmmunoglobulin concentration .They are classified as follows : 11.2%
have IgA deficiency , 5.1% have IgM deficiency and 4.8% have IgG
deficiency.These results revealed that Ig deficiency is associated with
shigellosis .