Effect of Hyperprolactinaemia on concentration of immunoglobulins and complement components in a series of infertile Iraqi women

Abstract

The present study was designed to detection the imunoglobulins concentration and  complement compenent effects by hyperprolactinaemia The sample included patients, who were attending the Institute for Embryo Research and Infertility Treatment for diagnosis and  treatment In Bagdad city during the period 200 -April -to -200 -Septemper . primary infertile females patients with hyperprolactinaemia (age range: 20 – 40 years) were  investigated.The  collected serum was tested for the determination of prolactin levels using a miniVidas system. (serum level of prolactin ≥ ng/ml), the total patients were divided into three groups; I ( patients), II ( patients) and III ( patients), Their serum prolacin levels were 22-29, 30-39 and ≥ 40 ng/ml, respectively.
( single radial immunodiffusion test) , used to Quantitative Measurement of Immunoglobulins(IgA, IgG and IgM) and Complement components C3 and C4 which was developed by( Mancini et al. 1965).  The immunoglobulins (IgA, IgG and IgM) showed a significant increased total level in the sera of
total patients when compared with controls, (265.5 vs. 225.3, 1423 vs. 1076 and 266 vs. 188 mg/dl, respectively  With respect to complement components, the serum levels of C3 and C4 were slightly decreased in the patients, but the difference did not reach a statistical level .