The Effect of Profen and Vitamin C on rate of Sperm abnormalties and Weight of Testes and Prostate Gland of Male White Mice

Abstract

The present research was conducted on 36 white mice of similar weights by using one of the non-
steroid anti-inflammation drugs, namely profen. Vitamin C was used to assess the sperm abnormality; the testes mean weight, and prostate gland weight. The mice were divided into three equal groups. The mice of the first group were injected with profen (200mg. /kg. for each), the second was injected with profen and vitamin C (200mg. /kg. for each), and the third group was the control one. The mice of the first two groups were injected, in the peritoneum membrane once a day for a month. The treatment with profen resulted into an increase in the percentage of the abnormal sperms compared to the control group (10.74 ± 1.92 and 4.17 ± 1.26 respectively). The results have shown that the treatment with vitamin C and profen led to a decrease in the percentage of the abnormal sperms compared to the profen group (10.74 ± 1.92). The statistical analysis has shown considerable differences (P< 0.05) for this group compared to the control one; this means that the use of vitamin C with profen decreases the percentage of abnormality effected by profen. Also, there happened a considerable decrease (P< 0.05) in
the testes weight treated with profen (2526.8 ± 6.48 mg.) compared to the control group (3203 ± 9.9 mg.). However, the testes weight was high in the group treated with profen and vitamin C (3245.5 ± 13.8 mg.)